Open AccessSulfonylurea action re‐revisited
Author(s) -
Seino Susumu,
Zhang ChangLiang,
Shibasaki Tadao
Publication year - 2010
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/j.2040-1124.2010.00014.x
Subject(s) - medicine , sulfonylurea , action (physics) , diabetes mellitus , endocrinology , physics , quantum mechanics
Sulfonylureas (SU), commonly used in the treatment of type 2 diabetes mellitus (T2DM), stimulate insulin secretion by inhibiting adenosine triphosphate (ATP)‐sensitive K + (K ATP ) channels in pancreatic β‐cells. SU are now known to also activate cyclic adenosine monophosphate (cAMP) sensor Epac2 (cAMP‐GEFII) to Rap1 signaling, which promotes insulin secretion. The different effects of various SU on Epac2/Rap1 signaling, as well as K ATP channels in different tissues, underlie the diverse pancreatic and extra‐pancreatic actions of SU. (J Diabetes Invest, doi: 10.1111/j.2040‐1124.2010.00014.x, 2010)