Open AccessIntravenous Administration of Azumolene to Reverse Malignant Hyperthermia in Swine
Author(s) -
Do Carmo P. L.,
ZapataSudo G.,
Trachez M. M.,
Antunes F.,
Guimarães S. E. F.,
Debom R.,
Rizzi M. D. R.,
Sudo R. T.
Publication year - 2010
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.2010.0556.x
Subject(s) - malignant hyperthermia , medicine , dantrolene , halothane , anesthesia , acidosis , contracture , pco2 , respiratory acidosis , metabolic acidosis , muscle relaxant , caffeine , surgery , calcium
Background: The efficacy of intravenous (IV) administration of azumolene (Az), an analogue 30‐fold more soluble than dantrolene, on pigs susceptible to malignant hyperthermia (MH) is incompletely understood. Objective: To evaluate efficacy of Az on MH crisis in pigs. Animals: Eight normal (MHN) and 7 susceptible to MH (MHS) pigs (Landrace × Large White × Pietran). Methods: Prospective, laboratory trial. Hypermetabolic crisis was observed in MHS pigs, but not in MHN pigs, after a combined administration of inhaled halothane (1.5%) and IV injection of succinylcholine (SCh; 2.5 mg/kg). Susceptibility was confirmed using a caffeine and halothane contracture test. Az was administered 15 minutes after administration of SCh. Results: Respiratory acidosis (pH 7.16 ± 0.02; P co 2 , 46.2 ± 9.1 mmHg, HCO 3 , 22.5 ± 2.3 mmol/L), fever (38.2 ± 1.1°C), cardiac arrhythmias, and muscle contracture were observed in MHS pigs. MHS pigs (n = 5) treated with Az (2 mg/kg IV) survived the crisis with attenuation of signs (pH 7.30 ± 0.10; P co 2 , 36.3 ± 4.5 mmHg; HCO 3 , 22.9 ± 2.3 mmol/L) and recovery of normal muscle tone and cardiac rhythm. Conclusions and Clinical Importance: Az represents a possible substitute for dantrolene to reverse MH crisis in susceptible pigs.