Open AccessPolymicrogyria in Standard Poodles
Author(s) -
Jurney C.,
Haddad J.,
Crawford N.,
Miller A.D.,
Winkle T.J. Van,
Vite C.H.,
Sponenberg P.,
Inzana K.D.,
Cook C.R.,
Britt L.,
O'Brien D.P.
Publication year - 2009
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.2009.0338.x
Subject(s) - polymicrogyria , medicine , occipital lobe , parietal lobe , magnetic resonance imaging , electroencephalography , hydrocephalus , frontal lobe , pathology , radiology , psychiatry
Background: Polymicrogyria is a disorder of cerebrocortical migration resulting in increased numbers of small, disorganized gyri. This disorder occurs in Standard Poodles and in cattle. Objectives: To describe the clinical, electroencephalographic, imaging, and histopathologic features in poodles with polymicrogyria. Animals: Five Standard Poodles with histologically confirmed polymicrogyria. Methods: Retrospective case series. Cases were obtained by personal communication with 1 of 2 authors (TJVW, DPO). Results: All dogs had cortical blindness and other neurologic abnormalities including gait and behavioral changes. Magnetic resonance imaging of 3 dogs showed multiple disorganized gyri, which were especially apparent on T2‐weighted dorsal plane images. Electroencephalogram (EEG) of 1 dog revealed epileptiform discharges, including both spike and spike and wave discharges with voltage maximum potentials over the parietal/occipital region. The EEG supported that the repetitive behavior displayed by the dog was a complex partial motor seizure. One dog had concurrent hydrocephalus. All dogs had occipital lobe involvement and 2 dogs had involvement of other lobes. Clinical Importance: The cases presented here demonstrate a larger age range (7 weeks to 5 years) and a decreased frequency of associated hydrocephalus when compared with the previous report.