Open AccessA Novel Leukoencephalomyelopathy of Leonberger Dogs
Author(s) -
Oevermann A.,
Bley T.,
Konar M.,
Lang J.,
Vandevelde M.
Publication year - 2008
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.2008.0068.x
Subject(s) - medicine , ataxia , leukodystrophy , spinal cord , neuropathology , pathology , white matter , neurological examination , myelopathy , anatomy , magnetic resonance imaging , surgery , radiology , disease , psychiatry
Many different degenerative diseases of the canine central nervous system (CNS) have been described involving white matter in various breeds. These include Afghan Hound myelopathy and a similar disease in Kooiker dogs, globoid cell leukodystrophy of various breeds, oligodendroglial dysplasia in Bullmastiffs, cavitating leukodystrophy of Dalmatians, hound ataxia, leukoencephalomyelopathy of Rottweiler dogs, and myelopathies in Jack Russell and Fox Terriers. In the Leonberger dog, no degenerative diseases of the nervous system have been described apart from an inherited polyneuropathy. This report describes the clinical signs, magnetic resonance imaging (MRI) findings, and neuropathology of a novel neurodegenerative disorder affecting the white matter of brain and spinal cord in 2 Leonberger dogs.