Open AccessEvaluation of Plasma C‐Terminal Atrial Natriuretic Peptide in Healthy Cats and Cats with Heart Disease
Author(s) -
Hori Y.,
Yamano S.,
Iwanaga K.,
Kano T.,
Tanabe M.,
Uechi M.,
Kanai K.,
Nakao R.,
Hoshi F.,
Higuchi S.
Publication year - 2008
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.2007.0007.x
Subject(s) - cats , medicine , atrial natriuretic peptide , cardiology , endocrinology , radioimmunoassay , heart failure , cardiomyopathy , fissipedia
Background: The clinical implications of evaluating C‐terminal atrial natriuretic peptide (ANP) concentration in cats are still controversial. Hypothesis: The objective of this study was to investigate the relationship between plasma C‐terminal ANP concentration and left atrial pressure (LAP) in healthy cats with volume overload (study 1), and to compare plasma C‐terminal ANP in normal cats and cats with cardiomyopathy (study 2). Animals: Five healthy adult cats were used in study 1, and clinically healthy cats (n=8) and cats with cardiomyopathy (n=14) were used in study 2. Methods: In study 1, cats were anesthetized and given acetated Ringer's solution (100 mL/kg/h for 60 minute) via the cephalic vein. Hemodynamic measurements and blood samples, collected from the jugular vein, were performed at 10‐min intervals. In study 2, blood samples from normal cats and cats with cardiomyopathy were collected from the cephalic vein. The plasma C‐terminal ANP concentration was determined by radioimmunoassay for human α‐ANP. Results: In study 1, volume overload significantly increased the C‐terminal ANP concentration and LAP from baseline. The C‐terminal ANP concentration was strongly correlated with the mean LAP. In study 2, age, E wave velocity, and the ratios of the left atrium to aorta were significantly higher in the cats with cardiomyopathy compared with the normal cats. The C‐terminal ANP concentration was significantly higher in the cats with cardiomyopathy compared with the normal cats. Conclusions and Clinical Importance: Our results suggest that the measurement of plasma C‐terminal ANP in cats may provide additional information for the diagnosis of heart disease.