Open AccessTissue Doppler Imaging for Detection of Radial and Longitudinal Myocardial Dysfunction in a Family of Cats Affected by Dystrophin‐Deficient Hypertrophic Muscular Dystrophy
Author(s) -
Chetboul Valérie,
Blot Stephane,
Sampedrano Carolina Carlos,
Thibaud JeanLaurent,
Granger Nicolas,
Tissier Renaud,
Bruneval Patrick,
Gaschen Frederic,
Gouni Vassiliki,
Nicolle Audrey P.,
Pouchelon JeanLouis
Publication year - 2006
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.2006.tb02909.x
Subject(s) - medicine , hypertrophic cardiomyopathy , cats , muscle hypertrophy , kitten , cardiology , doppler imaging , cardiomyopathy , muscular dystrophy , left ventricular hypertrophy , fabry disease , disease , heart failure , diastole , blood pressure
Diagnosis of feline hypertrophic cardiomyopathy currently is based on the presence of myocardial hypertrophy detected using conventional echocardiography. The accuracy of tissue Doppler imaging (TDI) for earlier detection of the disease has never been described. The objective of this sudy was to quantify left ventricular free wall (LVFW) velocities in cats with hypertrophic muscular dystrophy (HFMD) during preclinical cardiomyopathy using TDI. The study animals included 22 healthy controls and 7 cats belonging to a family of cats with HFMD (2 affected adult males, 2 heterozygous adult females, one 2.5‐month‐old affected male kitten, and 2 phenotypically normal female kittens from the same litter). All cats were examined via conventional echocardiography and 2‐dimensional color TDI. No LVFW hypertrophy was detected in the 2 carriers or in the affected kitten when using conventional echocardiography and histologic examination, respectively. The LVFW also was normal for 1 affected male and at the upper limit of normal for the 2nd male. Conversely, LVFW dysfunction was detected in all affected and carrier cats with HFMD when using TDI. TDI consistently detects LVFW dysfunction in cats with HFMD despite the absence of myocardial hypertrophy. Therefore, TDI appears more sensitive than conventional echocardiography in detecting regional myocardial abnormalities.