Open AccessComparison of Glomerular Filtration Rate between Greyhounds and Non‐Greyhound Dogs
Author(s) -
Drost Wm Tod,
Couto C. Guillermo,
Fischetti Anthony J.,
Mattoon John S.,
Iazbik Cristina
Publication year - 2006
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.2006.tb02894.x
Subject(s) - medicine , renal function , creatinine , urinalysis , urea , breed , clearance , urology , blood urea nitrogen , urine , endocrinology , zoology , biochemistry , biology
Greyhounds have significantly higher serum creatinine (SCr) concentration than do non‐Greyhound dogs that may be attributable to differences in glomerular filtration rate (GFR). By means of plasma clearance of technetium Tc 99m diethylenetriaminepentaacetic acid, GFR was measured in 10 Greyhounds and 10 non‐Greyhound dogs with normal findings of physical examination, CBC, serum biochemical analysis, and urinalysis. Dogs were fed the same diet for a minimum of 6 weeks before GFR data collection. Greyhounds had significantly higher mean ± SD GFR (3.0±0.1 vs 2.5±0.2 ml/min/kg; P = .01) and SCr concentration (1.8±0.1 vs 1.5±0.1 mg/dL; P = .03) than did non‐Greyhound dogs, but the serum urea nitrogen (SUN) concentration was not significantly different (18±1 vs 18±2 mg/dL; P = .8). Therefore, the higher SCr concentration in Greyhounds is not attributable to decreased GFR, and may be associated with the high muscle mass in the breed. Healthy Greyhounds have higher GFR than do non‐Greyhound dogs.