Open AccessUse of Glargine and Lente Insulins in Cats with Diabetes Mellitus
Author(s) -
Weaver Kelli E.,
Rozanski Elizabeth A.,
Mahony Orla M.,
Chan Daniel L.,
Freeman Lisa M.
Publication year - 2006
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.2006.tb02851.x
Subject(s) - medicine , fructosamine , insulin glargine , cats , diabetes mellitus , endocrinology , insulin , gastroenterology , hypoglycemia
The goals of this study were to compare the efficacy of once‐daily administered Glargine insulin to twice‐daily administered Lente insulin in cats with diabetes mellitus and to describe the use of a high‐protein, low‐carbohydrate diet designed for the management of diabetes mellitus in cats. All cats with naturally occurring diabetes mellitus were eligible for inclusion. Baseline testing included a physical examination, serum biochemistry, urinalysis and urine culture, serum thyroxine concentration, and serum fructosamine concentration. All cats were fed the high‐protein, low‐carbohydrate diet exclusively. Cats were randomized to receive either 0.5 U/kg Lente insulin q12h or 0.5 U/kg Glargine insulin q24h. Re‐evaluations were performed on all cats at weeks 1, 2, 4, 8, and 12, and included an assessment of clinical signs, physical examination, 16‐hour blood glucose curve, and serum fructosamine concentrations. Thirteen cats completed the study (Lente, n = 7, Glargine, n = 6). There was significant improvement in serum fructosamine and glucose concentrations in all cats but there was no significant difference between the 2 insulin groups. Four of the 13 cats were in complete remission by the end of the study period (Lente, n = 3; Glargine, n = 1). The results of the study support the use of once‐daily insulin Glargine or twice‐daily Lente insulin in combination with a high‐protein, low‐carbohydrate diet for treatment of feline diabetes mellitus.