Open AccessFloppy Kid Syndrome Caused by D‐Lactic Acidosis in Goat Kids
Author(s) -
Bleul Ulrich,
Schwantag Silvia,
Stocker Hans,
Corboz Louis,
Grimm Felix,
Engels Monika,
Borel Nicole,
Lutz Hans,
Schonmann Marietta,
Kähn Wolfgang
Publication year - 2006
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.2006.tb01819.x
Subject(s) - medicine , metabolic acidosis , anion gap , acidosis , lactic acidosis , base excess , sodium bicarbonate , bicarbonate , endocrinology , chemistry
Background : Goat kids with floppy kid syndrome have metabolic acidosis, muscle weakness, and depression but no dehydration. Hypothesis : D‐Lactate is the major component of acidemia in goat kids with floppy kid syndrome. Animals : Fifty‐five goat kids with floppy kid syndrome (group F) and 35 clinically healthy goat kids (group C). Methods : Clinical, biochemical, microbiologic, virologic, parasitologic, and pathologic examinations. Results : The animals in group F had a blood pH of 7.13 ± 0.11 and a base excess of ‐17.8 ± 3.8 mM, which were both lower than the values in the control animals (pH, 7.32 ± 0.31; base excess, ‐0.1 ± 2.7 mM; P < .001). Floppy kids had a significantly larger anion gap than healthy kids (31.2 ± 3.7 versus 21.5 ± 8.5 mM; P < .001). The concentration of L‐lactate was lower in floppy kids than in healthy kids (0.67 ± 0.49 versus 1.60 ± 1.02 mM), but the concentration of D‐lactate was higher in floppy kids (7.43 ± 2.71 versus 0.26 ± 0.24 mM; P < .001). Intravenous and oral administration of sodium bicarbonate in floppy kids resulted in a significant increase in blood pH and base excess and a decrease in the anion gap ( P < .001). In addition, the concentration of L‐lactate increased ( P = .039). Conclusions and Clinical Importance : Metabolic acidosis in goat kids with floppy kid syndrome is caused by an increase in the plasma concentration of D‐lactate.