Open AccessInsulin‐Like Growth Factors and Recurrent Hypoglycemia Associated with Renal Cell Carcinoma in a Horse
Author(s) -
Swain J.M.,
Pirie R.S.,
Hudson N.P.H.,
Else R.W.,
Evans H.,
McGorum B.C.
Publication year - 2005
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.2005.tb02738.x
Subject(s) - medicine , fenbendazole , ivermectin , horse , prednisolone , hypoglycemia , veterinary medicine , surgery , insulin , anthelmintic , paleontology , biology
The case was examined at the Easter Bush Veterinary Hospital, The University of Edinburgh. A 520 kg, 6‐year‐old Thoroughbred gelding was referred for evaluation of acute onset profound depression, head pressing, and lack of response to external stimuli. The horse had a history of moderate weight loss over several months despite adequate nutrition and a good appetite. Previous episodes of weakness had been observed following administration of anthelmintics, namely, alternate doses of pyrantel and ivermectin, administered every 8 weeks. In an attempt to eliminate a possible parasitic cause of weight loss, over the 7 days prior to presentation, the referring veterinary surgeon treated the horse with a 5‐day course of fenbendazole a (7.5 mg/kg PO q24h) and moxidectin b (0.4 mg/kg PO), 2 days later. A 5‐day course of prednisolone c (1 mg/kg PO q24h) was initiated on the same day as the fenbendazole. This dose was then tapered to 0.5 mg/kg PO q24h, and was still being administered at the time of presentation.