Open AccessComparison of Ultrasonography, Computed Tomography, and Single‐Photon Emission Computed Tomography for the Detection and Localization of Canine Insulinoma
Author(s) -
Robbena Joris H.,
Pollak Yvonne W.E.A.,
Kirpensteijn Jolle,
Boroffka Susanne A.E.B.,
Ingh Ted S.G.A.M.,
Teske Erik,
Voorhout George
Publication year - 2005
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.2005.tb02652.x
Subject(s) - insulinoma , medicine , radiology , palpation , emission computed tomography , lymph node , single photon emission computed tomography , positron emission tomography , scintigraphy , nuclear medicine , pancreas , pathology
Accurate preoperative detection, localization, and staging of the primary tumor and metastases are essential for the selection of appropriate candidates for surgery. In dogs with insulinoma, preoperative assessment usually is performed with transabdominal ultrasonography (US). There are no reports on the use of computed tomography (CT) for this purpose. The preoperative use of somatostatin receptor scintigraphy (SRS) recently has been advocated for the identification of insulinoma and gastrinoma in dogs, but its accuracy remains to be established. In this report US, CT, and single‐photon emission computed tomography (SPECT) with [ 111 In‐DTPA‐D‐Phe 1 ]‐octreotide (a specific form of SRS) were compared for their effectiveness in detecting and localizing primary and metastatic insulinoma in dogs. Findings at surgery or postmortem examination served as control. Of 14 primary insulinomas, 5, 10, and 6 were correctly identified by US, CT, and SPECT, respectively. No lymph node metastases were detected by US or SPECT. CT identified 2 of 5 lymph node metastases but also identified 28 false‐positive lesions. Two of 4 livers were found to be positive for metastases by 1 of the imaging techniques. US can be used for the initial evaluation of dogs with hypoglycemia. Although CT identifies most primary tumors, intraoperative inspection and palpation of the pancreas is still superior. SPECT appears as effective as US and CT in detecting insulinomas. Future developments in preoperative imaging techniques might improve current methods of canine insulinoma detection.