Open AccessSerum Thymidine Kinase Activity: An Alternative to Histologic Markers of Cellular Proliferation in Canine Lymphoma
Author(s) -
Madewell Bruce R.
Publication year - 2004
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.2004.tb02592.x
Subject(s) - medicine , thymidine kinase , lymphoma , canine lymphoma , cancer research , cell cycle , kinase , thymidine , cell growth , pathology , nucleotide salvage , immunology , dna , cancer , biology , biochemistry , nucleotide , virus , herpes simplex virus , gene
Thymidine kinase (TK) is a cellular enzyme which is involved in a salvage pathway of DNA synthesis. It is activated in the G1/S phase of the cell cycle, and its activity has been shown to correlate with the proliferative activity of tumor cells⃜Clin‐ical studies have reported high serum TK concentrations in a variety of neoplasias. The majority of these studies concerned hematological malignancies. TK seems to be a useful marker in non‐Hodgkins lymphoma, where it correlates with clinical stag‐ing and provides marked prognostic information on (progres‐sion‐free) survival.