Open AccessEffects of Trimethoprim‐Sulfadiazine on Thyroid Function of Horses
Author(s) -
Rothschild Chantal M.,
Hines Melissa T.,
Breuhaus Babetta,
Gay John,
Sellon Debra C.
Publication year - 2004
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.2004.tb02563.x
Subject(s) - medicine , sulfadiazine , thyroid function , trimethoprim , dermatology , thyroid , antibiotics , microbiology and biotechnology , biology
Trimethoprim‐sulfadiazine was administered to horses in a randomized, placebo controlled study to determine the effects of potentiated sulfonamides on thyroid function in normal horses. The treatment group included eight horses that received trimethoprim‐sulfadiazine mixed with molasses orally at 30 mg/kg once daily for eight weeks. The control group included 8 horses that received an oral placebo (flour mixed with molasses) once daily for the same period. Thyroid function was evaluated prior to initiation of treatment and after 8 weeks of treatment. Serum concentrations of total and free triiodothyronine (T3), total and free thyroxine (T4), and thyroid stimulating hormone (TSH) were determined at rest and after a thyrotropin‐releasing hormone (TRH) stimulation test. There was no detectable difference between treatment and control groups.