Open AccessTrilostane Therapy for Treatment of Pituitary‐Dependent Hyperadrenocorticism in 5 Cats
Author(s) -
Neiger Reto,
Witt Angela L.,
Noble Ann,
German Alexander J.
Publication year - 2004
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.2004.tb00156.x
Subject(s) - medicine , cats , hypercortisolemia , endocrine system , diabetes mellitus , endocrinology , hormone
Hyperadrenocorticism is a rare syndrome in cats. Current medical therapy is unsatisfactory and prognosis for long‐term survival with surgical treatment is guarded. We report on 5 cats treated with the 3‐beta hydroxysteroid dehydrogenase inhibitor trilostane. Diagnosis was confirmed in all cats by endocrine testing. Three cats had concurrent diabetes mellitus. Trilostane reduced clinical signs and improved endocrine test results in all cats, but insulin requirements did not change and all continued to have some signs of hypercortisolemia. Two died or were euthanized after 16 and 140 days, whereas 3 were still alive 6, 11, and 20 months after the start of trilostane therapy. Trilostane ameliorates clinical signs of feline hyperadrenocorticism, but more research is needed before it can be recommended for treatment.