Open AccessPhotodynamic Therapy for the Treatment of Intranasal Tumors in 3 Dogs and 1 Cat
Author(s) -
Lucroy Michael D.,
Long Kevin R.,
Blaik Margaret A.,
Higbee Russell G.,
Ridgway Tisha D.
Publication year - 2003
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.2003.tb02509.x
Subject(s) - medicine , photodynamic therapy , nasal administration , cats , adverse effect , photosensitizer , nasal cavity , radiation therapy , anesthesia , surgery , pharmacology , chemistry , organic chemistry
Three dogs and 1 cat with intranasal tumors were treated with pyropheophorbide‐a‐hexyl ether‐based photodynamic therapy (PDT). PDT was well tolerated by all the animals, and no adverse effects from photosensitizer injection, such as cutaneous photosensiti‐zation, were observed. Facial swelling was observed in all animals after each PDT treatment but resolved spontaneously within 72 hours after treatment. All animals had a decrease in severity of epistaxis, frequency of sneezing, and amount of nasal discharge after PDT. Clinical signs were controlled for variable time, although long‐term responses were comparable with radiation therapy in 2 animals. This small case series demonstrates another application for PDT in veterinary medicine. On the basis of these findings, further studies are warranted to define the role of PDT in the management of intranasal tumors in dogs and cats.