Open AccessThe Effect of Dosing Interval on the Efficacy of Misoprostol in the Prevention of Aspirin‐Induced Gastric Injury
Author(s) -
Ward Deborah M.,
Leib Michael S.,
Johnston Spencer A.,
Marini Michele
Publication year - 2003
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.2003.tb02449.x
Subject(s) - misoprostol , medicine , aspirin , placebo , anesthesia , dosing , vomiting , gastroenterology , pregnancy , genetics , alternative medicine , pathology , abortion , biology
The effect of twice‐daily administration of misoprostol on aspirin‐induced gastric injury was evaluated. Twenty‐four random‐source dogs were divided into groups that received aspirin and misoprostol as follows: group I, aspirin 25 mg/kg PO q8h and placebo PO q8h; group II, aspirin 25 mg/kg PO q8h and misoprostol 3 μg/kg PO q8h; group III, aspirin 25 mg/kg PO q8h, misoprostol 3 μg/kg PO q12h, and placebo PO q24h; and group IV, aspirin 25 mg/kg PO q8h, misoprostol 3 μg/kg PO q24h, and placebo PO q12h for 28 days. Gastroscopy was performed on days — 9, 5, 14, and 28. Visible lesions were scored on a scale of 1 (mucosal hemorrhage) to 11 (perforating ulcer). No difference in total score was identified between groups I and IV on any day. Median total scores for groups II and III were significantly ( P ≤ .05) lower compared to groups I and IV on day 5. Group III had a significantly lower score ( P ≤ .05) than groups I, II, and IV on day 28. This study suggests that misoprostol 3 μg/kg PO q12h is as effective as misoprostol 3 μg/kg PO q8h in preventing aspirin‐induced gastric injury in this model. However, misoprostol 3 (μg/ kg PO q8h was less effective in preventing aspirin‐induced gastric injury on days 14 and 28 than in previous studies. No difference among numbers of dog‐days of vomiting, diarrhea, or anorexia was detected among groups.