Open AccessIdiopathic Hypereosinophilic Syndrome in 3 Rottweilers
Author(s) -
Sykes Jane E.,
Weiss Douglas J.,
Buoen Lance C.,
Blauvelt Melissa M.,
Hayden David W.
Publication year - 2001
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.2001.tb01251.x
Subject(s) - eosinophilia , medicine , hypereosinophilic syndrome , bone marrow , pathology , immunoglobulin e , eosinophilic , infiltration (hvac) , eosinophilic gastroenteritis , leukemia , gastroenterology , immunology , antibody , physics , thermodynamics
Three Rottweilers with marked peripheral eosinophilia and infiltration of the liver, spleen, lungs, and bone marrow with eosinophils were diagnosed with idiopathic hypereosinophilic syndrome (IHES). Mean serum immunoglobulin E concentrations were markedly high. On cytogenetic analysis, no evidence of karyotypic abnormalities was found in bone marrow aspirates. Despite an extensive search, no underlying cause for the eosinophilia could be identified. In this study, cytogenetic analysis and measurement of serum IgE concentrations were used to differentiate IHES and eosinophilic leukemia.