Open AccessSerum Alpha 1‐Acid Glycoprotein Concentrations in Healthy and Tumor‐Bearing Cats
Author(s) -
Selting K.A.,
Ogilvie G.K.,
Lana S.E.,
Fettman M.J.,
Mitchener K.L.,
Hansen R.A.,
Richardson K.L.,
Walton J.A.,
Scherk M.A.
Publication year - 2000
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.2000.tb02267.x
Subject(s) - medicine , cats , glycoprotein , orosomucoid , alpha (finance) , endocrinology , microbiology and biotechnology , surgery , biology , construct validity , patient satisfaction
The purpose of this study was to evaluate alpha 1‐acid glycoprotein (AGP) concentrations in tumor‐bearing and healthy cats. The hypothesis of the present study was that AGP concentrations would be significantly increased in tumor‐bearing cats. Serum from 51 healthy and 97 tumor‐bearing, client‐owned cats was harvested at the time of presentation and stored at — 80°C until assayed. Cats with measurable, histologically confirmed malignancies, and healthy cats of similar ages were included. Serum was assayed for AGP concentration by using a radial immunodiffusion method. AGP concentrations were significantly ( P = .0051) higher in tumor‐bearing (763 ± 595 μg/mL; mean ± SD) when compared to healthy cats (501 ± 377 μg/mL; mean ± SD). Of the tumorbearing cats, 35 had carcinomas, 33 had sarcomas, and 26 had discrete, round cell tumors. AGP concentrations were 645 ± 62 μg/mL, 660 ± 540 μg/mL, and 967 ± 860 μg/mL, respectively, and there were no significant differences among the groups.