Open AccessCanine Hemangiosarcoma Treated with Standard Chemotherapy and Minocycline
Author(s) -
Sorenmo Karin,
Duda Lili,
Barber Lisa,
Cronin Kim,
Sammarco Carl,
Usborne Amy,
Goldschmidt Michael,
Shofer Frances
Publication year - 2000
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.2000.tb02247.x
Subject(s) - medicine , hemangiosarcoma , minocycline , chemotherapy , doxorubicin , metastasis , angiosarcoma , oncology , surgery , cancer , gastroenterology , antibiotics , microbiology and biotechnology , biology
Standard treatments for canine hemangiosarcoma include surgery and chemotherapy with doxorubicin, but in spite of treatment most dogs with this disease die within 6 months of diagnosis. Tumor growth and metastasis are angiogenesis dependent. Antian‐giogenic drugs such as minocycline may provide therapeutic benefits in cancer patients. The purpose of this prospective study was to evaluate the efficacy of chemotherapy with doxorubicin and minocycline, an antiangiogenic agent, in dogs with hemangiosarcoma. Eighteen dogs with histologically confirmed hemangiosarcoma of any stage were treated with doxorubicin, cyclophospha‐mide, and minocycline. Complete staging was performed before and during the treatment period to assess remission status and response to therapy. No statistically significant difference was found in survival between the dogs treated with chemotherapy and minocycline, and historical controls consisting of dogs that received chemotherapy alone. Postmortem examination revealed widespread metastasis, suggesting that minocycline is ineffective as a single antiangiogenic agent in canine hemangiosarcoma.