Open AccessA Comparison of Doxorubicin and COP for Maintenance of Remission in Cats With Lymphoma
Author(s) -
Moore Antony S.,
Cotter Susan M.,
Frimberger Angela E.,
Wood Carrie A.,
Rand William M.,
L'Heureux Deborah A.
Publication year - 1996
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.1996.tb02083.x
Subject(s) - medicine , cats , vincristine , prednisone , doxorubicin , cyclophosphamide , lymphoma , chemotherapy , maintenance therapy , surgery
Thirty‐eight cats with lymphoma were treated with vincristine, cyclophosphamide, and prednisone (COP). They were randomized at entry to receive maintenance chemotherapy consisting of either single‐agent doxorubicin or continued COP therapy, starting on week 4 of treatment and continuing for 6 months or until relapse. Eighteen cats achieved complete clinical remission after COP induction chemotherapy. The median remission duration for 11 cats continuing to receive COP was 83 days, which was significantly shorter than for 7 cats that received doxorubicin (281 days). Thus, doxorubicin should be considered a well‐tolerated and efficacious agent for the maintenance of remission in cats with lymphoma.