Open AccessClinical and Immunohistochemical Characterization of Thymic Lymphosarcoma in a Heifer
Author(s) -
Alexander Andrew N.,
Constable Peter D.,
Meier William A.,
French Richard A.,
Morin Dawn E.,
Lowry Jennifer E.,
Hoffman Walter E.
Publication year - 1996
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.1996.tb02062.x
Subject(s) - medicine , immunohistochemistry , pathology , cd5 , cd3 , polyclonal antibodies , jugular vein , anatomy , antibody , lymphoma , antigen , cd8 , immunology
A 2–year‐old Holstein heifer with a swollen brisket, jugular vein distention, muffled heart sounds, tachycardia, and free gas bloat was examined. Thymic lymphosarcoma was suspected based on a negative agar gel immunodiffusion test for bovine leukemia virus, presence of atypical lymphocytes in pleural fluid, and detection of a mass in the thoracic inlet. Right‐sided cardiac catheterization was performed, and markedly increased jugular venous pressures (41 mm Hg) with a pressure gradient of 29 mm Hg immediately cranial to the heart indicated constriction of the cranial vena cava. Immunohistochemical staining of formalin fixed, paraffin‐embedded tissue sections of the tumor using a rabbit anti‐human T cell, CD3 polyclonal antibody confirmed that the neoplastic lymphocytes were of thymic origin. J Vet Intern Med 1996;275–278. Copyright © 1996 by the American College of Veterinary Internal Medicine .