Open AccessResponse of Canine Mast Cell Tumors to Treatment With Oral Prednisone
Author(s) -
McCaw Dudley L.,
Miller Margaret A.,
Ogilvie Gregory K.,
Withrow Stephen J.,
Brewer William G.,
Klein Mary Kay,
Bell Ford W.,
Anderson Sharon K.
Publication year - 1994
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.1994.tb03259.x
Subject(s) - prednisone , medicine , mast cell , complete remission , gastroenterology , cell , pathology , chemotherapy , immunology , biology , genetics
Twenty‐five dogs with naturally occurring mast cell tumors were treated with daily oral prednisone (1 mg/kg) for 28 days. Five dogs (20%) had reduction in tumor volume and were considered responders. Four of these underwent partial remission and one underwent complete remission. Survival times for the five responders were 3, 5, 6, 7.5, and greater than 28 months, respectively. We therefore conclude that prednisone is effective in some canine mast cell tumors. Further studies are indicated to determine the most effective dose of prednisone, the appropriate duration of treatment, and the efficacy in more benign mast cell tumors, and in combination with other forms of therapy.