Open AccessFanconi's Syndrome in a Dog With Primary Hypoparathyroidism
Author(s) -
Freeman Lisa M.,
Breitschwerdt Edward B.,
Keene Bruce W.,
Hansen Bernie
Publication year - 1994
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.1994.tb03249.x
Subject(s) - medicine , endocrinology , polyuria , hypoparathyroidism , fanconi syndrome , polydipsia , parathyroid hormone , calcium , hypokalemia , calcitriol , calcium metabolism , urinary calcium , diabetes mellitus , kidney
An 11 ‐year‐old castrated male mixed breed dog was referred for evaluation of muscle twitching, polyuria, polydipsia, anorexia, and periocular alopecia. Primary hypoparathyroidism was diagnosed by documenting decreased serum concentrations of parathyroid hormone and ionized calcium. Neurological, gastrointestinal, and dermatological signs resolved after calcium repletion. Initially, 1,25‐dihydroxycholecalcif erol PO was required to correct the hypocalcemia. Dihydrotachysterol, in combination with oral calcium supplementation, was used for long‐term maintenance of normal serum calcium concentration. Aminoaciduria, glucosuria, and hyperchloremic metabolic acidosis were consistent with a diagnosis of Fanconi's syndrome. This diagnosis was further supported by the presence of hypokalemia and increased urinary fractional excretion of sodium, potassium, calcium, phosphorus, and magnesium. Renal tubular dysfunction resolved after oral supplementation with calcium and vitamin D 3 . Fanconi's syndrome in this dog may have been caused by decreased serum concentration of 1,25‐dihydroxycholecalciferol, which was secondary to decreased parathyroid hormone production.