Open AccessUnexpected Neurotoxicity in Dogs Receiving a Cyclophosphamide, Dactinomycin, and 5‐Fluorouracil Chemotherapy Protocol
Author(s) -
Hammer Alan S.,
Carothers Marcia A.,
Harris Cheryl L.,
O'Keefe Deborah A.,
Ayl Rodney D.,
Peterson Janet L.,
Shank Karen A.,
Couto C. Guillermo
Publication year - 1994
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.1994.tb03225.x
Subject(s) - medicine , fluorouracil , cyclophosphamide , neurotoxicity , chemotherapy , pharmacology , toxicity
An inexpensive combination chemotherapy protocol containing cyclophosphamide, dactinomycin, and 5‐fluorouracil was evaluated in dogs with carcinomas. Fifteen dogs were entered in this study, and there were 1 complete response and 2 partial responses among 12 evaluable dogs. However, 6 of 15 dogs (40%) developed neurotoxicity. The neurotoxicity of this protocol was compared with a previous 5‐fluorouracil‐containing protocol and found to be significantly higher. Due to the unacceptably high rate of neurotoxicity, this protocol cannot be recommended for use in dogs with cancer.