Open AccessIdentification of an Intrinsic Platelet Function Defect in Spitz Dogs
Author(s) -
Boudreaux Mary K.,
Crager Cynthia,
Dillon A.R.,
Stanz Kimberly,
ToivioKinnucan Maria
Publication year - 1994
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.1994.tb03204.x
Subject(s) - platelet , medicine , adenosine diphosphate , bleeding time , platelet activating factor , thrombin , serotonin , platelet membrane glycoprotein , endocrinology , platelet aggregation , pathology , receptor
A recently identified intrinsic platelet function defect in 2 Spitz dogs is described. Both affected dogs had a history of chronic intermittent bleeding primarily from the nasal, oral, and gastrointestinal mucosa. Platelet aggregation in response to adenosine diphosphate (ADP), collagen, and platelet activating factor (PAF) was absent; however, platelet shape change did occur. Platelets aggregated in response to gamma thrombin, although a delayed onset and a reduced velocity of aggregation were present. Platelet 14 C‐serotonin release was diminished in response to collagen and PAF. Glycoprotein Illa was detected on the surface of platelets by flow cytometry. Platelets were morphologically normal under light and electron microscopy. Two male Spitz dogs, related to one of the affected dogs, did not have a bleeding diathesis. Collagen‐induced platelet aggregation, however, was diminished in these 2 dogs. This platelet defect most closely resembles the defect described in Basset hounds.