Open AccessFeline Immunodeficiency Virus Infection Clinicopathologic Findings in 90 Naturally Occurring Cases
Author(s) -
Sparkes A. H.,
Hopper C. D.,
Millard W. G.,
GruffyddJones T. J.,
Harbour D. A.
Publication year - 1993
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.1993.tb03174.x
Subject(s) - medicine , monocytosis , neutrophilia , leukocytosis , feline immunodeficiency virus , cats , eosinopenia , leukopenia , neutropenia , hepatosplenomegaly , anemia , lymphocytosis , immunology , gamma globulin , immunodeficiency , immunosuppression , feline leukemia virus , pathology , virus , disease , viral disease , bone marrow , antibody , lentivirus , chemotherapy , toxicity , immune system
In 90 cats with naturally occurring feline immunodeficiency virus (FIV) infection, the clinicopathologic changes seen at the time of first diagnosis of FIV infection included lymphopenia (29%), neutrophilia (27%), monocytosis (23%), anemia (18%), leukocytosis (13%), leukopenia (13%), neutropenia (11%), hyperproteinemia (38%), and hyperglobulinemia (25%). Forty‐nine (54%) of the cats showed multiple hematologic abnormalities, and a further 24 (17%) had a single abnormality. The most consistent changes in serum protein electrophoretic patterns were increases in the concentrations of alpha2 globulin and gammaglobulin subfractions. Although there is no established system for staging the degree of immunosuppression in cats infected with FIV, cytopenias appeared to be more commnn in cats with advanced clinical signs of disease.