Open AccessIntracavitary Cisplatin Chemotherapy Experience with Six Dogs
Author(s) -
Moore Antony S.,
Kirk Claudia,
Cardona Aglaia
Publication year - 1991
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.1991.tb00953.x
Subject(s) - medicine , cisplatin , pleural effusion , chemotherapy , mesothelioma , effusion , surgery , gastroenterology , pathology
Six dogs with a median age of 7 years (range = 5–14 years) were presented for signs referable to thoracic or abdominal effusion associated with neoplasia of the body cavities. Intracavitary cisplatin was administered at 50 mg/m 2 every 4 weeks for a median of 2.5 treatments (mean = 3, range = 1–6). Three dogs with pleural mesothelioma had complete resolution of effusion for 289, 129, and > 306 days without evidence of tumor growth. Resolution of effusion occurred after one treatment in two dogs and after two treatments in one dog. In three dogs with carcinomatosis of unknown origin, complete responses was seen in two dogs after one treatment for 255 and > 807 days, respectively. Intracavitary chemotherapy with cisplatin was associated with palliation and control of malignant pleural and/or abdominal effusion in five of six dogs. Toxicity was minimal, and this method of therapy should be further explored in dogs with similar malignancies.