Open AccessChanges in Factor VIII:Coagulant Activity and von Willebrand Factor Antigen Concentration After Subcutaneous Injection of Desmopressin in Dogs with Mild Hemophilia A
Author(s) -
Mansell Peter D.,
Parry Bruce W.
Publication year - 1991
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.1991.tb00946.x
Subject(s) - desmopressin , medicine , von willebrand factor , nasal administration , plasma concentration , endocrinology , anesthesia , pharmacology , platelet
Four German Shepherd dogs with mild hemophilia A were given Desmopressin (Minirin intranasal solution, Ferring, Malmo, Sweden) subcutaneously at a range of doses in a controlled blind study. No substantial change in plasma FVIH activity was observed 0.5,1, 2,4, or 6 hours after administration of Desmopressin. Plasma von Willebrand factor antigen concentrations increased rapidly after doses of 0.4, 1.0, 2.0, and 5.0 μg/kg to mean values of 140%, 127%, 120%, and 140% of baseline, respectively. The duration of this increase was dependent on the dose of Desmopressin injected.