Open AccessSevere Neutropenia Associated With Griseofulvin Therapy in Cats With Feline Immunodeficiency Virus Infection
Author(s) -
Shelton Grady H.,
Grant Chris K.,
Linenberger Michael L.,
Abkowitz Janis L.
Publication year - 1990
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.1990.tb03130.x
Subject(s) - medicine , neutropenia , cats , griseofulvin , feline immunodeficiency virus , human immunodeficiency virus (hiv) , virology , immunology , dermatology , viral disease , chemotherapy , lentivirus
Griseofulvin administration was associated with the development of absolute neutropenia in six of seven (86%) cats with feline immunodeficiency virus (FIV) infection. The neutropenia was severe (<400 neutrophils//il) in four of the six affected cats, and one cat died from sepsis. Neutrophil counts returned to baseline values within 15 days after drug withdrawal in all surviving cats. No symptoms or hemato‐logic abnormalities were observed in four normal (FIV‐seronegative) cats treated with the same lot of griseofulvin at equivalent doses. Neutropenia recurred in two of two FIV‐seropositive cats upon griseofulvin rechallenge. Cats with FIV infections appear to be at increased risk for griseofulvin‐associated neutropenia. This phenomenon may be analogous to the increased frequency of antibiotic‐induced neutropenias observed in humans infected with the human immunodeficiency virus.