Open AccessEndotoxic Shock
Author(s) -
Hardie Elizabeth M.,
KruseElliott Kris
Publication year - 1990
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.1990.tb03119.x
Subject(s) - medicine , prostacyclin , tumor necrosis factor alpha , platelet activating factor , platelet , shock (circulatory) , immunology , thromboxane a2 , lipid signaling , interleukin 6 , thromboxane , endotoxic shock , inflammation , pharmacology
Endotoxic shock is a complex phenomenon resulting from systemic release of inflammatory mediators. Endotoxin interacts with inflammatory cells, platelets, and vascular endothelium. Cytokines, such as tumor necrosis factor and interleukins, and lipid mediators (platelet activating factor, thromboxane, prostacylin, leukotrienes) are released. These primary mediators act synergistically to cause many of the harmful effects associated with endotoxemia. Multiple secondary mediators are released in response to the primary mediators, compounding the damage. The end result is the species‐specific clinical syndrome recognized as endotoxemia.