Open AccessImmunity Targeting Common Core Antigens of Gram‐Negative Bacteria
Author(s) -
Tyler Jeff W.,
Cullor James S.,
Spier Sharon J.,
Smith Bradford P.
Publication year - 1990
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.1990.tb00870.x
Subject(s) - medicine , immunity , immunology , gram negative bacteria , microbiology and biotechnology , sepsis , immunization , antigen , immune system , biology , escherichia coli , gene , biochemistry
Antibodies against common gram‐negative core antigens can provide protection against environmental, commensual, and contagious bacteria that cause life‐threatening gram‐negative sepsis/endotoxemia. Cross‐protective immunity may be effective against many common livestock diseases, including neonatal coliform septicemia, coliform mastitis, septic metritis, and severe enteritis. The greatest potential benefit of cross‐protective immunity may be realized in the reduction of ill‐thrift and mortality of neonates. The use of active and passive immunization against core antigens common to gram‐negative bacteria has been successful in human beings, laboratory animals, and livestock. Protection has been observed following challenge with either heterologous endotoxin or unrelated, live, virulent gram‐negative bacteria. (Journal of Veterinary Internal Medicine 1990; 4:17–25)