Open AccessHalf‐Body Radiotherapy in the Treatment of Canine Lymphoma
Author(s) -
Laing Elizabeth J.,
Fitzpatrick Peter J.,
Binnington AIlen G.,
Norris AIan M.,
Mosseri AIlen,
Rider Walter D.,
Valli V. E.,
Baur Angela
Publication year - 1989
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.1989.tb03087.x
Subject(s) - medicine , radiation therapy , lymphoma , canine lymphoma , pneumonitis , bone marrow , chemotherapy , radiation pneumonitis , surgery , gastroenterology , lung
In a Phase I–II study, half‐body radiotherapy was used to treat 14 dogs with multicentric lymphoma. Using this technique, a radiation dose of 7 Gray (Gy) was delivered to one half of the body in a single exposure. The other half of the body was treated approximately 28 days later. Of 14 treated dogs, 11 (79%) had a measurable decrease in tumor size. Five dogs achieved a complete or partial remission with a mean duration of 102 and 54 days, respectively. In predicting response to therapy, poor prognostic factors included large tumor burdens, advanced disease stage, and chemotherapy‐resistant tumors.