Open AccessA Retrospective Study of Aldosterone Secretion in Normal and Adrenopathic Dogs
Author(s) -
Golden Dennis L.,
Jr Clinton D. Lothrop
Publication year - 1988
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.1988.tb02807.x
Subject(s) - medicine , aldosterone , endocrinology , adrenocorticotropic hormone , basal (medicine) , acth stimulation test , radioimmunoassay , cosyntropin , stimulation , dose , hormone , insulin
A retrospective study on stored plasma from normal dogs and dogs with pituitary dependent hyperadre‐nocorticism (PDH), pituitary dependent hyperadrenocorticism controlled by mitotane (o, p'‐DDD),* iatrogenic hyperadrenocorticism, and hypoadrenocorticism was conducted to determine if alterations in aldosterone production exist in these disorders. The plasma aldosterone concentration (PAC) was measured by radioimmunoassay immediately before and 1 hour after adrenocorticotropic hormone (ACTH)† administration (0.5 IU/kg, intravenously [IV]). PACs increased significantly when ACTH was administered to normal dogs. Dogs with PDH had a lower baseline PAC, but their PAC increased to levels similar to that of normal dogs after ACTH administration. In dogs with PDH controlled by o, p'‐DDD therapy, the response to ACTH was significantly less than that of normal dogs or dogs with untreated PDH. Dogs with iatrogenic hyperadrenocorticism had a lower baseline and post‐ACTH PAC than normal dogs. Dogs with hypoadrenocorticism had a normal basal PAC, but showed no significant increase in PAC following ACTH administration. These findings suggest that PACs are significantly altered in a variety of adrenal diseases, and that the ACTH stimulation test may be useful when evaluating aldosterone secretion in adrenopathic disorders. In addition, at therapeutic dosages, o, p'‐DDD treatment was associated with a decrease in basal and post‐ACTH PACs in dogs with PDH.