Open AccessEffect of Thyrotropin Storage on Thyroid‐Stimulating Hormone Response Testing in Normal Dogs
Author(s) -
DVM D. S. Bruyette,
Nelson R. W.,
Bottoms G. D.
Publication year - 1987
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.1987.tb01993.x
Subject(s) - medicine , thyrotropin releasing hormone , thyroid , endocrinology , hormone
The stability of reconstituted, refrigerated thyrotropin was evaluated. Thyrotropin (TSH) was reconstituted at the start of the study and stored at 4C. A TSH stimulation test was performed in eight healthy, euthyroid dogs at weekly intervals for 1 month. In seven of eight dogs, there was no significant difference ( P < 0.05) between the post‐TSH T 3 concentrations and the post‐TSH T 4 concentrations for the duration of the study. For one dog, the post‐TSH T 4 concentration was below the normal post‐TSH T 4 range following the administration of reconstituted TSH that had been stored 4 weeks. The T 3 response to the TSH, however, was normal. This dog responded normally to freshly reconstituted TSH. The results of this study suggest that reconstituted bovine TSH can be stored at 4 o C for at least 3 weeks without loss of biologic activity in the dog.