Open AccessPrimary Ciliary Dyskinesia in the Dog
Author(s) -
Morrison Wallace B.,
Wilsman Norman J.,
Fox Leslie E.,
Farnum Cornelia E.
Publication year - 1987
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.1987.tb01989.x
Subject(s) - primary ciliary dyskinesia , cilium , dynein , medicine , ciliary processes , microtubule , fixation (population genetics) , dynein atpase , anatomy , ophthalmology , pathology , microbiology and biotechnology , ciliary body , biology , bronchiectasis , lung , population , environmental health
Electron microscopy was used to diagnose primary ciliary dyskinesia in a litter of English pointer dogs and in a golden retriever dog. A technique of membrane solubilization, fixation, and negative staining with glutaraldehyde tannic acid identified abnormally constructed central and B microtubules in respiratory cilia from dogs with primary ciliary dyskinesia. Shortened outer dynein arms commonly associated with primary ciliary dyskinesia actually represents the absence of a specific subset of the three most peripheral components of the whole outer dynein arm structure.