Open AccessPlatelet Aggregation in Feline Cardiomyopathy
Author(s) -
Helenski Cecelia A.,
Ross James N.
Publication year - 1987
Publication title -
journal of veterinary internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 103
eISSN - 1939-1676
pISSN - 0891-6640
DOI - 10.1111/j.1939-1676.1987.tb01982.x
Subject(s) - cats , platelet , adenosine diphosphate , medicine , carnivora , platelet aggregation , fissipedia , cardiomyopathy , endocrinology , heart failure
Platelet aggregation in response to adenosine diphosphate (ADP) was evaluated in 16 healthy cats and in 10 cats with cardiomyopathy. The minimum threshold concentration of ADP required to induce irreversible (2nd‐phase) aggregation was determined in each cat. The minimum ADP concentration needed for 2nd‐phase aggregation in platelets from healthy cats ranged from 1 μM to 100 μM ADP, with 56% (9/16) requiring 100 μM ADP. Of the remaining seven normal cats, three had platelets responding irreversibly to 10 μM ADP, and four had platelets responding to 1 μM ADP. In cats with cardiomyopathy, the threshold concentrations ranged from 0.01 μM ADP to 10 μM ADP. Two cats had platelets responding irreversibly to 0.01 μM ADP, whereas another cat had a threshold response at 0.1 nM ADP. Platelets from the remaining seven cats with cardiomyopathy exhibited 2nd‐phase aggregation in response to 1 μM ADP (five cats) or 10 μM ADP (two cats). Platelet counts ranged from 210,000/mm 3 to 630,000/mm 3 in healthy cats and from 218,000/mm 3 to 624,000/mm 3 in cats with cardiomyopathy. There was no apparent correlation between the platelet count and the magnitude of the threshold aggregation response, as measured by lag phase and slope of the aggregation curves. The results indicate that some cats with cardiomyopathy have platelets that are hyperaggregable to ADP in vitro.