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Primary ureteral giant cell sarcoma in a P omeranian
Author(s) -
Rigas Johanna D.,
Smith Thomas J.,
Elena Gorman M.,
Valentine Beth A.,
Simpson Jennifer M.,
Seguin Bernard
Publication year - 2012
Publication title -
veterinary clinical pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 51
eISSN - 1939-165X
pISSN - 0275-6382
DOI - 10.1111/j.1939-165x.2011.00398.x
Subject(s) - giant cell , vimentin , pathology , desmin , sarcoma , cytokeratin , synaptophysin , biology , spindle cell sarcoma , cytopathology , immunohistochemistry , anatomy , cytology , medicine
An 8‐year‐old male neutered P omeranian dog was presented to the V eterinary T eaching H ospital at O regon S tate U niversity for surgical treatment of hydronephrosis of the left kidney and a left cranial abdominal mass. A primary ureteral mass was found during exploratory surgery, and the mass was resected and ureteral anastomosis was performed. Cytologic evaluation of the mass revealed 3 distinct cell populations, including a large number of multinucleated giant cells, a moderate number of thin spindle‐shaped cells, and cohesive clusters of transitional epithelial cells. The cytologic diagnosis was giant cell sarcoma. The diagnosis was confirmed by histologic examination, and immunohistochemical staining was performed. The spindle‐shaped cells and multinucleated giant cells were both immunoreactive for vimentin and spindle‐shaped cells for S ‐100. Tumor cells did not express wide‐spectrum cytokeratin, broad‐spectrum muscle actin, smooth muscle actin, sarcomeric actin, desmin, BLA 36, M ac 387, synaptophysin, neuron‐specific enolase, glial fibrillary acid protein, or von W illebrand factor. These findings are most consistent with an anaplastic sarcoma with giant cells. This is the first case report of a primary ureteral giant cell sarcoma in a dog.