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Hypercalcemia and high parathyroid hormone–related peptide concentration in a dog with a complex mammary carcinoma
Author(s) -
Bae Bokyoung,
Kim Chaewook,
Choi Ulsoo,
Choi Eunwha,
Jee Hyang,
Kim Daeyong,
Lee Changwoo
Publication year - 2007
Publication title -
veterinary clinical pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 51
eISSN - 1939-165X
pISSN - 0275-6382
DOI - 10.1111/j.1939-165x.2007.tb00446.x
Subject(s) - medicine , endocrinology , polydipsia , polyuria , mammary gland , malignancy , lethargy , parathyroid hormone , primary hyperparathyroidism , carcinoma , parathyroid hormone related protein , pathology , calcium , cancer , breast cancer , diabetes mellitus
A 10‐year‐old female Dachshund was presented with a history of mammary masses, slight lethargy, polyuria, and polydipsia. Physical examination findings included masses involving the first, second, and fourth mammary glands of the left side. The mandibular, axillary, and right popliteal lymph nodes were mildly enlarged. Serum chemistry results included hypercalcemia (13.9 mg/dL, reference interval 8.0–11.5 mg/dL). Although intact parathyroid hormone (PTH) concentration (1.05 pmol/L) was below the reference interval (2–13 pmol/L), PTH–related protein (PTHrP) concentration was markedly increased (9.40 pmol/L, reference value <2 pmol/L). The masses were surgically removed, and the histopathologic diagnosis was complex mammary carcinoma. Three weeks after surgery, serum total calcium concentration had decreased to 10.5 mg/dL. Resolution of the hypercalcemia and clinical signs supported a diagnosis of humoral hypercalcemia of malignancy associated with mammary gland carcinoma.