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Expression of Tissue Factor in Experimental Bovine Pneumonic Pasteurellosis and Endotoxemia
Author(s) -
Rashid Javed,
Weiss Douglas J.,
Murtaugh Michael P.,
Bach Ronald
Publication year - 1997
Publication title -
veterinary clinical pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 51
eISSN - 1939-165X
pISSN - 0275-6382
DOI - 10.1111/j.1939-165x.1997.tb00736.x
Subject(s) - tissue factor , spleen , pathology , pasteurella , pasteurellosis , biology , lung , thromboplastin , immunology , coagulation , medicine , pasteurella multocida , genetics , bacteria
Tissue factor (TF), a cell surface‐associated cofactor and activator of coagulation factor VII, has been implicated in the local and systemic activation of coagulation associated with sepsis. This study describes the pattern of TF expression in experimental bovine pneumonic pasteurellosis and endotoxemia. Immunohistochemical techniques were used to localize TF antigen in tissue sections. Tissue factor expression was not observed in tissues from control animals. In response to Pasteurella haemolytica challenge, TF was expressed within alveolar walls, by mononuclear inflammatory cells within alveoli, and in walls of arteries, arterioles, bronchi, and bronchioles. Tissue factor was not detected in unaffected lung, liver, spleen, lymph node or kidney tissue. Administration of Escherichia coli endotoxin intravenously resulted in tissue factor expression in lung, spleen, and lymph node tissue. Results of this study indicate that TF is expressed locally at sites of inflammation and systemically in endotoxemia. Therefore, TF may be involved in coagulation events associated with pneumonic pasteurellosis.