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The Potential Use of Plasma Glutamate Dehydrogenase Activity for the Evaluation of Hepatic Disease in the Cockatiel ( Nymphicus hollandicus )
Author(s) -
Battison Andrea L.,
Buczkowski Susan,
Archer F. Joy
Publication year - 1996
Publication title -
veterinary clinical pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 51
eISSN - 1939-165X
pISSN - 0275-6382
DOI - 10.1111/j.1939-165x.1996.tb00966.x
Subject(s) - glutamate dehydrogenase , glutamate receptor , enzyme , lactate dehydrogenase , enzyme assay , biology , kidney , skeletal muscle , endocrinology , medicine , biochemistry , pathology , chemistry , receptor
A reference interval for plasma glutamate dehydrogenase (GD) (E.C. 1.4.1.3) activity, of 0–8 IU/L, was established for the cockatiel (Nymphicus hollandicus). An automated modification of a commercial manual assay was used. This enzyme is considered liver specific in humans and numerous domestic animals, due to its organ distribution. A similar distribution was found in cockatiels in this study. Maximal enzyme activity was recovered from liver and kidney homogenate supernatants. Minimal activity was detected in skeletal muscle preparations. These results suggest a potential use for plasma GD activity in the evaluation of hepatocelluar injury/necrosis in cockatiels.