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Inherited Erythrocyte Pyruvate Kinase Deficiency in a Beagle Dog
Author(s) -
Giger Urs,
Mason Gail D.,
Wang Ping
Publication year - 1991
Publication title -
veterinary clinical pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 51
eISSN - 1939-165X
pISSN - 0275-6382
DOI - 10.1111/j.1939-165x.1991.tb00572.x
Subject(s) - pyruvate kinase deficiency , beagle , pyruvate kinase , hemolytic anemia , osteosclerosis , isozyme , medicine , biology , endocrinology , glycolysis , anemia , heinz body , pathology , hemoglobin , biochemistry , enzyme , metabolism
Summary A 1‐year‐old, female Beagle dog with minimal exercise intolerance was found to have a persistent, severe, and highly regenerative anemia, splenomegaly, and progressive osteosclerosis. Despite near‐normal in vitro erythrocyte pyruvate kinase (PK) activity, the authors diagnosed PK deficiency by demonstrating a glycolytic block at the PK step, the lack of normal R‐type PK isoenzyme, and the presence of M 2 ‐type PK in the animal's erythrocytes. The dam had half‐normal erythrocyte PK activity, which supports an autosomal recessive mode of inheritance. We conclude from our studies that close similarities exist between erythrocyte PK deficiency in Beagle, Basenji, and West Highland White Terrier dogs and that this form of PK deficiency may be more widespread than previously thought.