Premium
Spurious Hyperphosphatemia in a Dog With Chronic Lymphocytic Leukemia and an IgM Monoclonal Gammopathy
Author(s) -
Kristensen Annemarie T.,
Klausner Jeffrey S.,
Weiss Douglas J.,
Schultz Ronald D.,
Bell Ford W.
Publication year - 1991
Publication title -
veterinary clinical pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 51
eISSN - 1939-165X
pISSN - 0275-6382
DOI - 10.1111/j.1939-165x.1991.tb00568.x
Subject(s) - hyperphosphatemia , chronic lymphocytic leukemia , monoclonal gammopathy , medicine , multiple myeloma , lymphocytosis , monoclonal , paraproteins , leukemia , chemistry , gastroenterology , monoclonal antibody , immunology , antibody , calcium
Summary Spurious hyperphosphatemia was diagnosed in a 6‐year‐old, neutered female, mixed‐breed dog with chronic lymphocytic leukemia associated with an IgM monoclonal gammopathy. The spurious hyperphosphatemia was probably caused by paraprotein precipitation which interfered with the ASTRA 8 automated analyzer measurements. Serial dilutions of the sample did not change the phosphorus value. Another analyzer system in which a protein‐free sample was prepared prior to analysis gave a normal serum phosphorus concentration. There was a linear relationship between the amount of paraprotein and the measured total serum inorganic phosphate (r = 0.75). A review of 700 chemistry profiles from dogs and cats and a review of 36 cases with polyclonal gammopathy and 6 cases with monoclonal gammopathy did not reveal other cases of spurious hyperphosphatemia.