Premium
Platelet Function in the Racing Thoroughbred: Implication for Exercise‐Induced Pulmonary Hemorrhage
Author(s) -
Weiss Douglas J.,
McClay Carolyn B.,
Smith Clark M.,
Rao Gundu H.R.,
White James G.
Publication year - 1990
Publication title -
veterinary clinical pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 51
eISSN - 1939-165X
pISSN - 0275-6382
DOI - 10.1111/j.1939-165x.1990.tb00540.x
Subject(s) - medicine , pulmonary hemorrhage , platelet , pulmonary function testing , cardiology , lung
Summary Platelet function was evaluated in horses with exercise‐induced pulmonary hemorrhage (bleeder) and in control horses (nonbleeder). Platelet aggregation, secretion, and adhesion to rabbit aortic suben‐dothelium were similar for bleeders and nonbleeders. Platelets readily aggregated in response to ADP, thrombin, collagen, and arachidonic acid, but platelet secretion occurred only with high concentrations of thrombin. Platelets readily adhered to rabbit aortic subendothelium and tended to form large thrombi rather than platelet monolayers or aggregates. These data suggest that horses may be predisposed to thrombus formation and subsequent microvascular obstruction.