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An Hypothesis on the Etio‐Pathogenesis of Equine Inflammatory Joint Disease
Author(s) -
Auer David E.
Publication year - 1989
Publication title -
veterinary clinical pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 51
eISSN - 1939-165X
pISSN - 0275-6382
DOI - 10.1111/j.1939-165x.1989.tb00508.x
Subject(s) - pathogenesis , disease , joint disease , immunology , medicine , biology , virology , pathology , osteoarthritis , alternative medicine
Summary The role of oxygen‐derived free radicals is considered critical to the etio‐pathogenesis of equine inflammatory joint disease. In vivo, the superoxide radical in the joint may be derived either from activated polymorphonuclear leukocytes or from an ischemia/reperiusion cycle. In the presence of ferrous iron, it may generate the highly reactive hydroxy! radical (OH). Predisposing factors may include synovitis, exercise‐induced ischemia and minor traumatic injury to the joints. Unlike other inflammatory mediators, oxygen‐derived free radicals may damage tissue directly and these reactive species could account for the tissue injury and insidious onset of equine exercise‐induced degenerative joint disease.