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The Intravenous Bile Acid Loading Test in the Goat: Determination of a Procedural Protocol and Reference Values
Author(s) -
Hagemoser Wayne A.
Publication year - 1989
Publication title -
veterinary clinical pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 51
eISSN - 1939-165X
pISSN - 0275-6382
DOI - 10.1111/j.1939-165x.1989.tb00507.x
Subject(s) - bile acid , protocol (science) , liver function tests , medicine , pharmacology , chemistry , chromatography , pathology , alternative medicine
SUMMARY An intravenous bile acid loading test was performed on 16 goats using various dosages and sampling protocols. A recently developed enzymatic bile acid assay provided an economical and technologically simple method for bile acid analysis. Intravenous injection of bile salts into goats was well tolerated. Clearance times were rapid. A protocol for performance of the test was suggested and a practical reference range for T 1/2 clearance of 4 ± 1 minute was determined. Further investigations of this test in the assessment of liver function in the ruminant appear warranted.