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Dyserythropoiesis, Sideroblasts/Siderocytes and Hemoglobin Crystallization in a Dog
Author(s) -
Canfield P.J.,
Watsond A.D.J.,
Ratcliffed R.C.C.
Publication year - 1987
Publication title -
veterinary clinical pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 51
eISSN - 1939-165X
pISSN - 0275-6382
DOI - 10.1111/j.1939-165x.1987.tb00457.x
Subject(s) - reticulocytosis , bone marrow , pathology , hemoglobin , anemia , biology , peripheral blood , medicine , immunology , biochemistry
Summary Dyserythropoiesis characterized by enhanced intramedullary destruction, pathologic sidederoblasts and siderocytes, and hemoglobin crystallization was detected in a female Cocker Spaniel presented for poor exercise tolerance. Examination of peripheral blood revealed intraerythrocytic crystals, granulation of erythrocytes, nucleated erythroid cells, reticulocytosis and marked variation in erythrocyte morphology in the absence of anemia. Bone marrow examination revealed sideroblasts, a low M:E ratio and evidence of enhanced intramedullary destruction of erythroid cells. Electron microscopy of peripheral blood and bone marrow confirmed pathologic mitochondrial iron accumulation in erythroid cells and the presence of intraerythrocytic hemoglobin crystals. A cause for the hematologic changes was not identified. After the animal became clinically normal, siderocytes disappeared from peripheral blood but intraerythrocytic crystals and reticulocytosis persisted.