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Cytochemical Reactions in Cells from Leukemic Cats
Author(s) -
Grindem Carol B.,
Stevens Jerry B.,
Perman Victor
Publication year - 1985
Publication title -
veterinary clinical pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 51
eISSN - 1939-165X
pISSN - 0275-6382
DOI - 10.1111/j.1939-165x.1985.tb00855.x
Subject(s) - staining , cats , sudan black b , pathology , leukemia , bone marrow , periodic acid–schiff stain , esterase , acid phosphatase , alkaline phosphatase , cytochemistry , biology , feline leukemia virus , myelocytic leukemia , peroxidase , microbiology and biotechnology , chemistry , enzyme , immunology , medicine , biochemistry , ultrastructure
Summary Cytochemical staining for leukocyte alkaline phosphatase (LAP), nonspecific esterase (NSE), nonspecific esterase with fluoride inhibition (NSE‐F), periodic acid Schiff (PAS) reactivity, and peroxidase (PO) was valuable in identification of the neoplastic cell type in 10 leukemic cats. Staining both blood and bone marrow smears was often necessary for making the correct diagnosis. Cytochemical staining resulted in changing the morphologic diagnosis of leukemia in two of the 10 cats. Also, increased LAP activity, probably a marker for myelocytic leukemia in the cat, was observed in bone marrow cells from three nonleukemic, FeLV‐positivecats.