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Optimal Switching In Structured Treatment Interruption For Hiv Therapy
Author(s) -
Kim Won Hee,
Chung Han Byul,
Chung Chung Choo
Publication year - 2006
Publication title -
asian journal of control
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.769
H-Index - 53
eISSN - 1934-6093
pISSN - 1561-8625
DOI - 10.1111/j.1934-6093.2006.tb00280.x
Subject(s) - controllability , human immunodeficiency virus (hiv) , control theory (sociology) , medicine , computer science , optimal control , control (management) , mathematical optimization , mathematics , immunology , artificial intelligence
This paper proposes ‘optimal switching control during structured treatment interruption,’ which switches RTI and PI to reduce medication and establish long‐term immune response against HIV. The proposed method is compared with ‘optimized STI’ through numerical simulation. The proposed method results in a more rapid increase of CTLp, and thus total drug intake and the therapy period are reduced. HIV treatment simulation results are analyzed in terms of controllability. Due to the effect of PI, ‘optimal switching control during STI’ can achieve greater controllability more quickly than ‘optimized STI.’