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On Robust Stability And Sensitivity Of Circadian Rhythms
Author(s) -
Ogawa Kazuto,
Takekawa Nao,
Uchida Kenko,
Shibata Shigenobu
Publication year - 2006
Publication title -
asian journal of control
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.769
H-Index - 53
eISSN - 1934-6093
pISSN - 1561-8625
DOI - 10.1111/j.1934-6093.2006.tb00279.x
Subject(s) - circadian rhythm , rhythm , robustness (evolution) , sensitivity (control systems) , bacterial circadian rhythms , stability (learning theory) , chronobiology , biological system , biology , computer science , neuroscience , circadian clock , physics , machine learning , engineering , biochemistry , electronic engineering , acoustics , gene
We develop an approach to robustness analysis of circadian rhythms from the viewpoints of (local) robust stability of periodic trajectories and their period‐sensitivity, based on mathematical models. Our attention is directed to the core molecular model generating circadian rhythms in Drosophila, proposed by Goldbeter [1], for our approach to be illustrated. We consider two cases when the circadian rhythms are subjected to periodic forcing by light/dark (LD) cycles and when the circadian rhythms are under continuous darkness (DD). First, we propose conditions/algorithms for (local) robust stability, and show that the circadian rhythms generated by the core molecular model are (locally) robustly stable, in both LD and DD cases. Second, in DD case, we derive a formula of period sensitivity, and assess effects of (infinitesimal) parameter‐variations on the period of the circadian rhythms.