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Comparison of epirubicin hydrochloride and miriplatin hydrate as anticancer agents for transcatheter arterial chemoembolization of hepatocellular carcinoma
Author(s) -
Aramaki Takeshi,
Moriguchi Michihisa,
Bekku Emima,
Asakura Kouiku,
Sawada Akihiro,
Endo Masahiro
Publication year - 2013
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/j.1872-034x.2012.01100.x
Subject(s) - epirubicin , hepatocellular carcinoma , medicine , transcatheter arterial chemoembolization , adverse effect , gastroenterology , response evaluation criteria in solid tumors , toxicity , cancer , breast cancer , phases of clinical research
Aim The aim of this retrospective study was to compare the local control effects of transcatheter arterial chemoembolization ( TACE ) using epirubicin ( EPIR ) and that using miriplatin ( MPT ) for hepatocellular carcinoma ( HCC ). Methods Between J anuary 2010 and J uly 2011, 218 HCC cases were treated with TACE , including 69 cases using EPIR or MPT as initial treatment. All 69 patients were treated with iodized oil and gelatin sponge particles. The local control rate (modified Response Evaluation Criteria in Solid Tumors [ RECIST ] ver. 1.0), time to treatment failure ( K aplan– M eier and log–rank test) and adverse events were evaluated. Results Forty‐two cases were treated using EPIR , and 27 cases were treated using MPT . All 69 patients had no previous treatment with TACE or hepatic arterial infusion. No serious adverse events were observed in either group. The response rates, including complete response ( CR ) and partial response ( PR ), of the EPIR group and the MPT group were 85.7% and 81.5%, respectively, with a time to treatment failure of 5.1 and 7.5 months, respectively. Excluding whole liver TACE cases, time to treatment failure was 5.4 months for the EPIR group and 10.1 months for the MPT group. Conclusion In TACE naïve cases, there was no significant difference in local control between EPIR and MPT .